Angiotensin II as a mediator of tubulointerstitial injury
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چکیده
منابع مشابه
Angiotensin II as a mediator of tubulointerstitial injury.
a pivotal role in many of these above-tubulointerstitial fibrosis mentioned processes leading to tubulointerstitial scarring and tubular atrophy [3,4]. Cell culture studies investigating potential effects of ANG II on tubular cells and fibroblasts in the absence of haemodynamic alterations have contributed considerably to a better understanding of the multiple cellular actions of this Morpholog...
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BACKGROUND Chronic potassium (K+) deficiency, one of the well-known causes of renal tubulointerstitial injury, is associated with an alteration in vasoactive mediators including persistent generation of renal cortical angiotensin (Ang) II despite the suppression of plasma Ang II, and suppression of urinary nitrite/nitrate excretion. We tested the hypothesis that K+-deficiency-induced renal tubu...
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Angiotensin II (Ang II) and nitric oxide (NO) signaling pathways mutually regulate each other by multiple mechanisms. Ang II regulates the expression of NO synthase and NO production, whereas NO downregulates the Ang II type I (AT1) receptor. In addition, downstream effectors of Ang II and NO signaling pathways also interact with each other. A feedback mechanism between Ang II and NO is critica...
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Based on several important clinical trials, the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure 7 (JNC 7) approves the use of angiotensinconverting enzyme (ACE) inhibitors and/or angiotensin receptor blockers (ARBs) in the first-line treatment for hypertension in subjects with chronic renal insufficiency, in diabetic subj...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2000
ISSN: 1460-2385,0931-0509
DOI: 10.1093/ndt/15.suppl_6.61